LSBio
Human TNF Alpha Protein (Recombinant His)

Human TNF Alpha Protein (Recombinant His)

ProteinLSBio Guarantee
Expression SystemEscherichia coli (Prokaryotic)
Format:Lyophilized
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$268.00each
Catalog Number: LS-G27033-10

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Overview

Description
Tumor Necrosis Factor-Alpha (TNF-alpha) plays a major role in growth regulation, differentiation, inflammation, viral replication, tumorigenesis, and autoimmune diseases. Besides inducing hemorrhagic necrosis of tumors, TNF has been found to be involved in tumorigenesis, tumor metastasis, viral replication, septic shock, fever, inflammation, and autoimmune diseases including Crohn's disease, and rheumatoid arthritis as well as graft-versus-host disease. TNF alpha-1a is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells. Recombinant human Tumor Necrosis Factor-Alpha (rhTNF-alpha) produced in E. coli is a non-glycosylated polypeptide chain of 164 amino acids. A fully biologically active molecule, rhTNF-alpha has a molecular mass of 18.3kDa analyzed by reducing SDS-PAGE and is obtained by refolding and chromatographic techniques.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
APC1 protein | Cachectin | DIF | TNF | TNF Alpha | Tumor necrosis factor-alpha | TNF-alpha | TNF-a | TNFA | Tumor necrosis factor | macrophage-derived | monocyte-derived | TNFSF2
Origin Species
Human
NCBI GenBank
NM_000594|NP_000585.2
SwissProt
P01375

Protein

Expression System
Escherichia coli (Prokaryotic)
Fusion Tag
Hexahistidine Tag
Molecular Weight
18.3 kDa (SDS-PAGE)
Protein Type
Recombinant
Amino Acid Sequence
1MHHHHHHVRS SSRTPSDKPV AHVVANPQAE GQLQWLNRRA NALLANGVEL RDNQLVVPSE
61GLYLIYSQVL FKGQGCPSTH VLLTHTISRI AVSYQTKVNL LSAIKSPCQR ETPEGAEAKP
121WYEPIYLGGV FQLEKGDRLS AEINRPDYLD FAESGQVYFG IIAL

164 aa

Format

Purity
>95%
Conjugate/Label
Unconjugated
Endotoxin Level
< 1.0 EU/µg
Format
Lyophilized
Formulation
Lyophilized from PBS
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Stable at -80°c for up to 1 year. Upon reconstitution, store at 4°c for up to 4 weeks or at -20°c for up to 6 months.

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To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.