IL35 Antibody
Catalog Number: LS-C664115
6 sizes / from $321.00
Antibody: Mouse Monoclonal
Applications: Western Blot
Reactivity: Human
Format: Liquid
Human IL35 Protein (Recombinant)
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| Expression System | Human Embryonic Kidney 293 |
| Format: | Lyophilized |
$274.00each
Catalog Number: LS-G133801-2
Catalog Number: LS-G133801
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- Description
- Interleukin-35 is a glycosylated, heterodimeric protein consisting of the p35 subunit from IL-12 (IL-12a) and the β subunit from IL-27 (EBI3). IL-35 can be expressed by regulatory T-cells (Tregs), macrophages, and certain trophoblast and dendritic cells. It is induced in response to inflammation, and generally acts as an inflammation suppressor. IL-35 suppresses inflammation by exerting multiple activities, including the induction of regulatory T-cells and the suppression of Th17 cells. Recombinant Human IL-35 produced from HEK293 cells is a glycosylated protein, primarily heterodimeric, that migrates as a diffuse band centered at an apparent molecular weight of about 60 kDa by SDS-PAGE analysis under non-reducing conditions. Recombinant Human IL-35 expressed in HEK293 cells contains 406 amino acid residues and has a calculated molecular weight of 45.8 kDa.
- Category
- Proteins & Peptides > Proteins > Recombinant Proteins
- Origin Species
- Human
Protein
- Expression System
- Human Embryonic Kidney 293
- Molecular Weight
- 60 kDa or 45.8 kDa
- Protein Type
- Recombinant
- Amino Acid Sequence
1(Alpha-Sub unit)RNLPV ATPDPGMFPC LHHSQNLLRA VSNMLQKARQ TLEFYPCTSE61EIDHEDITKD KTSTVEACLP LELTKNESCL NSRETSFITN GSCLASRKTS FMMALCLSSI121YEDLKMYQVE FKTMNAKLLM DPKRQIFLDQ NMLAVIDELM QALNFNSETV PQKSSLEEPD181FYKTKIKLCI LLHAFRIRAV TIDRVMSYLN AS(Beta-Su bunit)RKGP PAALTLPRVQ241CRASRYPIAV DCSWTLPPAP NSTSPVSFIA TYRLGMAARG HSWPCLQQTP TSTSCTITDV301QLFSMAPYVL NVTAVHPWGS SSSFVPFITE HIIKPDPPEG VRLSPLAERQ LQVQWEPPGS361WPFPEIFSLK YWIRYKRQGA ARFHRVGPIE ATSFILRAVR PRARYYVQVA AQDLTDYGEL421SDWSLPATAT MSLGK
435 aa
Format
- Purity
- >90%
- Conjugate/Label
- Unconjugated
- Endotoxin Level
- Not Tested
- Format
- Lyophilized
- Formulation
- Sterile filtered through a 0.2-micron filter. Lyophilized from 10mM Sodium Phosphate, pH 7.4 + 500mM NaCl + 0.5% CHAPS
- Purity Measurement Method
- SDS-PAGE (Coomassie Stain)
Storage & Handling
- Storage Conditions
- Store at -20°C. Protect from moisture.
