LSBio
Human IL1RN Protein (Recombinant)

Human IL1RN Protein (Recombinant)

ProteinLSBio Guarantee
Expression SystemHuman Embryonic Kidney 293
Format:Lyophilized
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$259.00each
Catalog Number: LS-G27229-10

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Overview

Description
IL-1 Receptor Antagonist, also known as IL-1RA, ICIL-1RA, IRAP and IL-1RN, is a member of the interleukin 1 cytokine family. It is expressed by monocytes, neutrophils, macrophages, epithelial cells and fibroblasts. IL-1RA inhibits the activity of both IL-1alpha and IL-1beta, and modulates a variety of IL-1 related immune and inflammatory responses. It inhibits the activity of IL-1 by binding to the receptor IL-1R1 and preventing its association with the coreceptor IL-1RAP for signaling. Clinical studies are being conducted to investigate the use of IL-1RA in the treatment of sepsis, rheumatoid arthritis and chronic myelogenous leukemia.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
DIRA | IL-1ra | IL-1RN | IL1F3 | IL1RA | IL1RN | MVCD4 | IL1 inhibitor | IL1RN (IL1F3) | IRAP | ICIL-1RA | IL-1ra3
Origin Species
Human
NCBI GenBank
NM_000577|NP_000568.1
SwissProt
P18510

Protein

Expression System
Human Embryonic Kidney 293
Molecular Weight
18-23 kDa (SDS-PAGE)
Protein Type
Recombinant
Amino Acid Sequence
1RPSGRKSSKM QAFRIWDVNQ KTFYLRNNQL VAGYLQGPNV NLEEKIDVVP IEPHALFLGI
61HGGKMCLSCV KSGDETRLQL EAVNITDLSE NRKQDKRFAF IRSDSGPTTS FESAACPGWF
121LCTAMEADQP VSLTNMPDEG VMVTKFYFQE DE

152 aa

Format

Purity
>95%
Conjugate/Label
Unconjugated
Endotoxin Level
< 0.2 EU/µg
Format
Lyophilized
Formulation
Lyophilized from PBS
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 2 months.

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