LSBio
Human IGFBP7 / TAF Protein (Recombinant 6His, C-terminus)

Human IGFBP7 / TAF Protein (Recombinant 6His, C-terminus)

ProteinLSBio Guarantee
Expression SystemOther
Format:Lyophilized
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$294.00each
Catalog Number: LS-G137882-10

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Overview

Description
Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules. IGFBP7 contains an N-terminal IGFBP domain, followed by a Kazal-type serine proteinase inhibitor domain and a C-terminal immunoglobulin-like C2-type domain. Human and mouse IGFBP7 are highly homologous and share 94% aa sequence identity. It is expressed in many normal tissues and in cancer cells. It is abundantly expressed in high endothelial venules (HEVs) of blood vessels in the secondary lymphoid tissues. It binds IGF and insulin with very low affinity and has been shown to enhance the mitogenic actions of IGF and insulin. IGFBP7 also has IGF/insulin-independent activities. It interacts with heparan sulfate proteoglycans, type IV collagen, and specific chemokines. It supports weak cell adhesion, promotes cell spreading on type IV collagen, and stimulates the production of the potent vasodilator PGI2. It modulates tumor cell growth and has also been implicated in angiogenesis.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
AGM | FSTL2 | IGFBP-7v | IGFBP-rP1 | IGFBP7 | IBP-7 | Angiomodulin | RAMSVPS | MAC25 protein | PSF | TAF | Tumor-derived adhesion factor | IGF-binding protein 7 | IGFBP-7 | IGFBPRP1 | MAC25 | PGI2-stimulating factor
Origin Species
Human
NCBI GenBank
NM_001553
SwissProt
Q16270

Protein

Expression System
Other
Fusion Tag
Hexahistidine Tag
Protein Type
Recombinant
Amino Acid Sequence
1SSSDTCGPCE PASCPPLPPL GCLLGETRDA CGCCPMCARG EGEPCGGGGA GRGYCAPGME
61CVKSRKRRKG KAGAAAGGPG VSGVCVCKSR YPVCGSDGTT YPSGCQLRAA SQRAESRGEK
121AITQVSKGTC EQGPSIVTPP KDIWNVTGAQ VYLSCEVIGI PTPVLIWNKV KRGHYGVQRT
181ELLPGDRDNL AIQTRGGPEK HEVTGWVLVS PLSKEDAGEY ECHASNSQGQ ASASAKITVV
241DALHEIPVKK GEGAELHHHH HH

262 aa

Format

Purity
>95%
Conjugate/Label
Unconjugated
Endotoxin Level
< 1 EU/µg
Format
Lyophilized
Formulation
Lyophilized from a sterile solution in PBS, pH 7.4.
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Before reconstitution: short term; store at room temperature for up to 3 weeks, long term; store at -20°C. After Reconstitution: short term; store at 4°C to 7°C for up to 7 days, long term; Aliquot and store at -20°C for up to 3 months. Avoid freeze-thaw cycles.

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