LSBio
Human HBEGF / HB EGF Protein (Recombinant)

Human HBEGF / HB EGF Protein (Recombinant)

ProteinLSBio Guarantee
Expression SystemChinese Hamster Ovary
Format:Lyophilized
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$244.00each
Catalog Number: LS-G27105-5

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Overview

Description
Proheparin-binding EGF-like growth factor (HB-EGF), also known as DTR, DTS and HEGFL, is a member of the EGF family of mitogens. It is expressed in macrophages, monocytes, endothelial cells and muscle cells. HB-EGF signals through the EGF receptor to stimulate the proliferation of smooth muscle cells, epithelial cells and keratinocytes. Compared to EGF, HB-EGF binds the EGF receptor with higher affinity and is thus more mitogenic, probably due to its ability to bind to heparin and heparin sulfate proteoglycans. HB-EGF has been reported to act as a diphtheria toxin receptor, mediating endocytosis of the bound toxin.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
Dtr | DTS | DTSF | HEGFL | Diphtheria Toxin Receptor | HBEGF
Origin Species
Human
NCBI GenBank
NM_001945|NP_001936.1
SwissProt
Q99075

Protein

Expression System
Chinese Hamster Ovary
Molecular Weight
12-14 kDa (SDS-PAGE)
Protein Type
Recombinant
Amino Acid Sequence
1DLQEADLDLL RVTLSSKPQA LATPNKEEHG KRKKKGKGLG KKRDPCLRKY KDFCIHGECK
61YVKELRAPSC ICHPGYHGER CHGLSL

86 aa

Format

Purity
>95%
Conjugate/Label
Unconjugated
Endotoxin Level
< 0.2 EU/µg
Format
Lyophilized
Formulation
Lyophilized from PBS
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 2 months.

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