Overview

Description

BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino acid polypeptide chains. This 27.5 kDa protein is obtained by proteolytic processing of a biologically inactive precursor protein of 97.7 kDa. Recombinant Human BMP-13/CDMP-2 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.

Category

Proteins & Peptides > Proteins > Recombinant Proteins

Alternative Names

BMP13 | CDMP2 | GDF6 | GDF16 | KFS1 | KFM | Klippel-Feil syndrome | MCOP4 | KFSL | Klip-Feil malformation | Klippel-Feil malformation | SGM1 | MCOPCB6 | SCDO4 | GDF-6 | KFS

Origin Species

Human

NCBI GenBank

NM_001001557

SwissProt

Q6KF10