LSBio
Human DDC / DOPA Decarboxylase Protein (Recombinant His)

Human DDC / DOPA Decarboxylase Protein (Recombinant His)

ProteinLSBio Guarantee
Expression SystemEscherichia coli (Prokaryotic)
Format:Liquid
See all DDC antibodies →
$267.00each
Catalog Number: LS-G489-20

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Overview

Description
Dopa decarboxylase, also known as DDC, is a homodimeric, pyridoxal phosphate dependent enzyme. Dopa decarboxylase is a protein implicated in 2 metabolic pathways, synthesizing 2 important neurotransmitters: dopamine and serotonin which both play key roles in many clinical disorders, including Parkinson's disease. Dopa decarboxylase is found in different areas of the brain and is particularly abundant in basal ganglia. Recombinant human Dopa decarboxylase protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
AADC | DDC | DOPA decarboxylase
Origin Species
Human
NCBI GenBank
NM_000790|NP_000781.1
SwissProt
P20711

Protein

Expression System
Escherichia coli (Prokaryotic)
Fusion Tag
Hexahistidine Tag
Protein Type
Recombinant
Amino Acid Sequence
11-480aa|MG SSHHHHHHSS GLVPRGSHTR SMNASEFRRR GKEMVDYVAN YMEGIEGRQV
61YPDVEPGYLR PLIPAAAPQE PDTFEDIIND VEKIIMPGVT HWHSPYFFAY FPTASSYPAM
121LADMLCGAIG CIGFSWAASP ACTELETVMM DWLGKMLELP KAFLNEKAGE GGGVIQGSAS
181EATLVALLAA RTKVIHRLQA ASPELTQAAI MEKLVAYSSD QAHSSVERAG LIGGVKLKAI
241PSDGNFAMRA SALQEALERD KAAGLIPFFM VATLGTTTCC SFDNLLEVGP ICNKEDIWLH
301VDAAYAGSAF ICPEFRHLLN GVEFADSFNF NPHKWLLVNF DCSAMWVKKR TDLTGAFRLD
361PTYLKHSHQD SGLITDYRHW QIPLGRRFRS LKMWFVFRMY GVKGLQAYIR KHVQLSHEFE
421SLVRQDPRFE ICVEVILGLV CFRLKGSNKV NEALLQRINS AKKIHLVPCH LRDKFVLRFA
481ICSRTVESAH VQRAWEHIKE LAADVLRAER E

511 aa

Format

Purity
>95%
Conjugate/Label
Unconjugated
Endotoxin Level
Not Tested
Format
Liquid
Formulation
20 mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 10% glycerol.
Concentration
1 mg/mL
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Short term: store at 2°C to 8°C for up to 1 week. Long term: aliquot and store at -20°C to -80°C. Avoid freeze-thaw cycles.

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