LSBio
Human CNTF Protein (Recombinant)

Human CNTF Protein (Recombinant)

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Expression SystemEscherichia coli (Prokaryotic)
Format:Lyophilized
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$279.00each
Catalog Number: LS-G27102-10

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Overview

Description
Ciliary Neurotrophic Factor (CNTF) is a cytokine belonging to the Interleukin 6 (IL-6) family, which also includes IL-6, Oncostatin M, Leukemia Inhibitory Factor (LIF), and Cardiotrophin-1. Structurally, CNTF resembles a four-helix bundle composition, similar to the other members of the IL-6 family. The receptor for CNTF is composed of three parts: a gp130-like subunit common in the IL-6 receptor family, a LIF Receptor Beta subunit, and a CNTF specific a receptor subunit. Upon binding to the CNTF, the Beta subunit of the CNTF receptor will undergo tyrosine phosphorylation, and activate the intracellular JAK/STAT pathway. The main function of CNTF in vivo is to promote the differentiation and survival of a variety of neurons and glial cells, including sympathetic precursor cells and spinal motor neurons.Recombinant human Ciliary Neurotrophic Factor (rhCNTF) produced in E. coli is a single non-glycosylated polypeptide chain containing 199 amino acids. A fully biologically active molecule, rhCNTF has a molecular mass of 22.8 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
Ciliary neurotrophic factor | HCNTF | CNTF
Origin Species
Human
NCBI GenBank
NM_000614|NP_000605.1
SwissProt
P26441

Protein

Expression System
Escherichia coli (Prokaryotic)
Molecular Weight
22.8 kDa (SDS-PAGE)
Protein Type
Recombinant
Amino Acid Sequence
1AFTEHSPLTP HRRDLCSRSI WLARKIRSDL TALTESYVKH QGLNKNINLD SADGMPVAST
61DQWSELTEAE RLQENLQAYR TFHVLLARLL EDQQVHFTPT EGDFHQAIHT LLLQVAAFAY
121QIEELMILLE YKIPRNEADG MPINVGDGGL FEKKLWGLKV LQELSQWTVR SIHDLRFISS
181HQTGIPARGS HYIANNKKM

199 aa

Format

Purity
>95%
Conjugate/Label
Unconjugated
Endotoxin Level
< 0.2 EU/µg
Format
Lyophilized
Formulation
Lyophilized from PBS
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 2 weeks or at -20°c for up to 3 months.

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To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.