Overview

Description

Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils, also known as LARC (Liver and Activation-regulated Chemokine) and as Exodus. It can signal through the CCR6 receptor. MIP-3 alpha is chemotactic towards lymphocytes and dendritic cells. Additionally, it promotes the adhesion of memory CD4+ T cells and inhibits colony formation of bone marrow myeloid immature progenitors.Recombinant Human MIP-3a/CCL20 produced in E.coliis a single non-glycosylated polypeptide chain containing 70 amino acids. A fully biologically active molecule, rhMIP-3a/CCL20has a molecular mass of 8.0 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.

Category

Proteins & Peptides > Proteins > Recombinant Proteins

Alternative Names

Beta chemokine exodus-1 | CCL20 | Beta-chemokine exodus-1 | CKb4 | Exodus-1 | MIP-3a | MIP-3-alpha | LARC | ST38 | SCYA20 | C-C motif chemokine 20 | CC chemokine LARC | Mip-3alpha | MIP3A | Small-inducible cytokine A20

Origin Species

Human

NCBI GenBank

NM_004591|NP_004582.1

SwissProt

P78556