LSBio
Cynomolgus HAVCR2 / TIM-3 Protein (Recombinant 8His, N-terminus)

Cynomolgus HAVCR2 / TIM-3 Protein (Recombinant 8His, N-terminus)

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Expression SystemOther
Format:Lyophilized
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$283.00each
Catalog Number: LS-G137908-10

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Overview

Description
T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
HAVcr-2 | KIM-3 | Kidney injury molecule-3 | T cell immunoglobulin mucin 3 | Tim-3 | TIMD3 | T-cell membrane protein 3 | TIM3 | TIMD-3 | HAVCR2 | T cell immunoglobulin mucin-3 | CD366
Origin Species
Cynomolgus Monkey
NCBI GenBank
NM_032782
SwissProt
Q8TDQ0

Protein

Expression System
Other
Fusion Tag
Octahistidine Tag
Protein Type
Recombinant
Amino Acid Sequence
1HHHHHHHHSE VEYIAEVGQN AYLPCSYTPA PPGNLVPVCW GKGACPVFDC SNVVLRTDNR
61DVNDRTSGRY WLKGDFHKGD VSLTIENVTL ADSGVYCCRI QIPGIMNDEK HNVKLVVIKP
121AKVTPAPTLQ RDLTSAFPRM LTTGEHGPAE TQTPGSLPDV NLTVSNFFCE LQIFTLTNEL
181RDSGATIR

188 aa

Format

Purity
>95%
Conjugate/Label
Unconjugated
Endotoxin Level
< 1 EU/µg
Format
Lyophilized
Formulation
Lyophilized from a sterile solution in PBS, pH 7.4.
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Before reconstitution: short term; store at room temperature for up to 3 weeks, long term; store at -20°C. After Reconstitution: short term; store at 4°C to 7°C for up to 7 days, long term; Aliquot and store at -20°C for up to 3 months. Avoid freeze-thaw cycles.

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