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Coronavirus SARS-CoV-2 NSP8 protein (Recombinant 6His, C-terminus)

Coronavirus SARS-CoV-2 NSP8 protein (Recombinant 6His, C-terminus)

Expression SystemEscherichia coli (Prokaryotic)
Format:Liquid
$350.00each
Catalog Number: LS-G145883-10

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Overview

Description
Cleavage by the viral main protease, 3CLpro results in generating the nsp8 protein, The nsp8 protein has been shown to associate with several other nsps and to colocalize with these nsps in cytoplasmic complexes that are important for viral RNA synthesis. It forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers. Nsp8 was shown to have RNA-dependent RNA polymerase (RdRp) activity that could be involved in producing primers utilized by nsp12 which is normally accepted to be the RdRp for SARS-CoV.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Origin Species
Vir

Protein

Expression System
E.coli
Fusion Tag
6×His
Molecular Weight
25 kDa
Protein Type
Recombinant
Amino Acid Sequence
1Ala1-Gln19 8 of YP_00 9725304.1

29 aa

Format

Purity
>95%
Conjugate/Label
Unconj
Endotoxin Level
< 1.0 EU/µg
Format
Liquid
Formulation
Sterile solution in 20 mM Tris-HCl, pH 8.5, 150 mM NaCl, 10% Glycerol
Purity Measurement Method
SDS-PAGE

Storage & Handling

Storage Conditions
Store at less than -20°C for up to 6 months. Avoid freeze-thaw cycles.

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To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.