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Coronavirus SARS-CoV-2 NSP14 (exonuclease) protein (Recombinant 6His, N-terminus)

Coronavirus SARS-CoV-2 NSP14 (exonuclease) protein (Recombinant 6His, N-terminus)

ProteinLSBio Guarantee
Expression SystemEscherichia coli (Prokaryotic)
Format:Liquid
$350.00each
Catalog Number: LS-G145885-10

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Overview

Description
The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14.positive-stranded RNA genome of the coronaviruses is translated from ORF1 to yield polyproteins that are proteolytically processed into intermediate and mature nonstructural proteins (nsps). SARS-CoV 2 polyproteins incorporate 16 protein domains (nsps). The putative non-structural protein 2 (nsp2) of SARS-CoV plays an important role in viral transcription and replication, and is an attractive target for anti-SARS drug development.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Origin Species
Virus / Viral Antigen

Protein

Expression System
Escherichia coli (Prokaryotic)
Fusion Tag
Hexahistidine Tag
Molecular Weight
62.9 kDa
Protein Type
Recombinant
Amino Acid Sequence
1Ala1-Gln52 7 of YP_00 9725309.1

29 aa

Format

Purity
>85%
Conjugate/Label
Unconjugated
Endotoxin Level
< 1.0 EU/µg
Format
Liquid
Formulation
Sterile solution in PBS, pH 7.4, 10% Glycerol.
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Store at less than -20°C for up to 6 months. Avoid freeze-thaw cycles.

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