Overview

Description

Recombinant Bovine insulin-like growth factor I (IGF-I) is a recombinant protein corresponding to aa 50-119 of native bovine IGF-I. IGF-I is a secreted mitogenic polypeptide and member of the insulin gene family, produced primarily by the liver, which effects a wide range of cells and plays a key role in cell proliferation and growth, inhibition of apoptosis, and is linked with tumor cell growth. IGF-I signals by binding to the type 1 insulin-like growth factor receptor (IGF-IR) and also to the insulin receptor (IR), resulting in the activation of the AKT signaling pathway. IGF-I production is stimulated by growth hormone (GH) and can be hindered by GH insensitivity, deficiency in GH receptors or a malfunction in the post GH receptor signalling pathway.

Category

Proteins & Peptides > Proteins > Recombinant Proteins

Alternative Names

IGF-IA | IGF-IB | IGFI | IBP1 | IGF-I | IGF1 | Insulin-like growth factor 1 | Insulin-like growth factor I | Insulin-like growth factor IA | Insulin-like growth factor IB | Mechano growth factor | Somatomedin-C | IGF1A | MGF

Origin Species

Bovine

NCBI GenBank

NM_000618

SwissProt

P05019