Juvenile idiopathic arthritis fibroblast-like synoviocytes influence chondrocytes to alter BMP antagonist expression demonstrating an interaction between the two prominent cell types involved in endochondral bone formation. Megan M Simonds, Amanda R Schlefman, Suzanne M McCahan, Kathleen E Sullivan, Carlos D Rose, AnneMarie C Brescia. Pediatric rheumatology online journal. 2020 November;18:89.
PubMed: 33198759 · PMC: PMC7670793
Methotrexate inhibits BMP4 and abrogates the hypertrophic chondrocyte phenotype of synovial fibroblasts in juvenile idiopathic arthritis. Megan M Simonds, Samuel T Freer, Anne Marie C Brescia. Pediatric rheumatology online journal. 2024 January;22:6.
PubMed: 38166938 · PMC: PMC10763212