Positive WB detected in:Mouse lung tissue,U251 whole cell lysate;All lanes: YTHDC1 antibody at 3.4ug/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 85,83 kDa;Observed band size: 85 kDa;

YTHDC1 Antibody

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Polyclonal
Applications:	Enzyme-Linked Immunosorbent Assay, Western Blot
Reactivity:	Human, Mouse
Format:	Liquid

$300.00each

Catalog Number: LS-C501558-50

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Overview

Description: YTHDC1 antibody LS-C501558 is an unconjugated rabbit polyclonal antibody to YTHDC1 from human. It is reactive with human and mouse. Validated for ELISA and WB.
Application: ELISA, WB
Reactivity: Hu, Ms
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: Putative splicing factor YT521 | YT521 | YTH domain containing 1 | KIAA1966 | Splicing factor YT521-B | YT521-B | YTHDC1
UniProt Number: Q96MU7
NCBI GenBank: NP_588611.2
SwissProt: Q96MU7

Target

Target: Human YTHDC1
Antigen Species: Human
Epitope: Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602).
Gene Name: YTHDC1