YAP / YAP1 Antibody (Ser94)

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Antibody:	Rabbit Polyclonal
Applications:	Enzyme-Linked Immunosorbent Assay, Western Blot
Reactivity:	Human, Mouse, Rat
Format:	Liquid

$485.00each

Catalog Number: LS-C415675-0.1

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Description: YAP1 antibody LS-C415675 is an unconjugated rabbit polyclonal antibody to YAP1 (YAP) (Ser94) from human. It is reactive with human, mouse and rat. Validated for ELISA and WB.
Application: ELISA, WB
Reactivity: Hu, Ms, Rt
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: 65 kDa Yes-associated protein | YAP | Yes-associated protein beta | Yes-associated protein delta | Yorkie homolog | YAP1 | YAP2 | Yes-associated protein 1 | Yes-associated protein 2 | YKI | YAP65
Recommended Dilution: ELISA: 1:5000 - 1:20000
Recommended Dilution: WB: 1:1000 - 1:10000
UniProt Number: P46937
NCBI GenBank: NM_006106 | NP_006097.2
SwissProt: P46937

Target: Human YAP / YAP1
Antigen Species: Human
Epitope: YAP (Yes-associated protein) is a transcription coactivator in the Hippo tumor suppressor pathway and controls cell growth, tissue homeostasis and in organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteosomal degradation. YAP induces gene expression by binding to the TEAD family transcription factors. Dysregulation of the Hippo-YAP pathway is frequently observed in human cancers. AMPK directly phosphorylates YAP at Ser94, a residue essential for the interaction with TEAD, thus disrupting the YAP-TEAD interaction.
Gene Name: YAP1

Immunogen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser94 of human YAP1.
Immunogen Type: Synthetic Peptide (Linear)

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