Immunohistochemistry of paraffin-embedded human liver cancer using XBP1 Antibody at dilution of 1:100

XBP1 Antibody

Antibody:	Rabbit Polyclonal
Applications:	Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general)
Reactivity:	Human
Format:	Liquid

$300.00each

Catalog Number: LS-C500115-50

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Description: XBP1 antibody LS-C500115 is an unconjugated rabbit polyclonal antibody to human XBP1. Validated for ELISA, IF and IHC.
Application: ELISA, IF, IHC
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: X-box binding protein 1 | X-box-binding protein 1 | XBP2 | TREB5 | XBP-1 | XBP1
UniProt Number: P17861
NCBI GenBank: NM_005080 | NP_005071.2
SwissProt: P17861

Target: Human XBP1
Antigen Species: Human
Epitope: Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity).
Gene Name: XBP1