LSBio
XAF1 Antibody (HRP)

XAF1 Antibody (HRP)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay
Reactivity:Human
Format:Liquid
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$300.00each
Catalog Number: LS-C501167-50

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Overview

Description
XAF1 antibody LS-C501167 is an HRP-conjugated rabbit polyclonal antibody to human XAF1. Validated for ELISA.
Application
ELISA
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
BIRC4 binding protein | BIRC4-binding protein | BIRC4BP | HSXIAPAF1 | XIAP-associated factor 1 | XIAPAF1 | XAF1 | XIAP associated factor 1
UniProt Number
Q6GPH4
NCBI GenBank
NM_017523 | NP_059993.2
SwissProt
Q6GPH4

Target

Target
Human XAF1
Antigen Species
Human
Epitope
Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.
Gene Name
XAF1

Antibody

Host Species
Rabbit
Clonality
Polyclonal
Isotype
IgG

Immunogen

Immunogen
Recombinant Human XIAP-associated factor 1 protein (172-259AA)
Immunogen Type
Recombinant Immunogen

Format

Conjugate/Label
Horseradish Peroxidase
Format
Liquid
Formulation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Preservative
Yes
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

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To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.