Immunohistochemistry of paraffin-embedded human testis tissue using WNK1 Antibody at dilution of 1:100

WNK1 Antibody

Antibody:	Rabbit Polyclonal
Applications:	Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general)
Reactivity:	Human
Format:	Liquid

$300.00each

Catalog Number: LS-C502040-50

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Description: WNK1 antibody LS-C502040 is an unconjugated rabbit polyclonal antibody to human WNK1. Validated for ELISA, IF and IHC.
Application: ELISA, IF, IHC
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: Erythrocyte 65 kDa protein | HSAN2 | KIAA0344 | Kinase deficient protein | HWNK1 | PHA2C | PRKWNK1 | PSK | WNK1 | HSN2 | KDP
UniProt Number: Q9H4A3
NCBI GenBank: NM_018979 | NP_061852.3
SwissProt: Q9H4A3

Target: Human WNK1
Antigen Species: Human
Epitope: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).
Gene Name: WNK1