Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with B7-H4 Rabbit Recombinant Monoclonal Antibody (B7H4/2652R).
VTCN1 / B7-H4 Antibody (clone B7H4/2652R)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Recombinant Monoclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Paraffin |
| Reactivity: | Human |
| Format: | Liquid |
$379.00each
Catalog Number: LS-C751425-20
Catalog Number: LS-C751425
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- Description
- B7-H4 antibody LS-C751425 is an unconjugated rabbit recombinant monoclonal antibody to human B7-H4 (VTCN1). Validated for ELISA, Flow, IF and IHC.
- Application
- ELISA, FC, IF, IHC-P
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Recombinant Antibodies
- Alternative Names
- B7 superfamily member 1 | B7 Superfamily, member 1 | B7h.5 | B7S1 | B7H4 | PRO1291 | VCTN1 | VTCN1 | RP11-229A19.4 | B7 family member, H4 | B7-H4 | B7X | Protein B7S1
- UniProt Number
- Q7Z7D3
- NCBI GenBank
- NM_024626 | NP_078902.2
- SwissProt
- Q7Z7D3
Recommended Dilution
| Application | Dilution |
|---|---|
| ELISA | 2 - 4 ug/ml |
| FC | 1 - 2 µg/10E6 cells |
| IF/ICC | 1 - 2 µg/ml |
| IHC-P | 1 - 2 µg/ml |
Target
- Target
- Human VTCN1 / B7-H4
- Antigen Species
- Human
- Epitope
- T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.
- Gene Name
- VTCN1
Antibody
- Host Species
- Rabbit
- Clonality
- Recombinant Monoclonal
- Clone
- B7H4/2652R
- Isotype
- IgG
- Origin Species
- Human
Immunogen
- Immunogen
- Recombinant human B7-H4 protein fragment. Antigen Molecular Weight: 35 kDa
- Immunogen Type
- Recombinant Protein Fragment
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
- Concentration
- 200 µg/mL
- Preservative
- Yes
- Purification Method
- Protein A/G Affinity
Storage & Handling
- Storage Conditions
- Store at 2°C to 8°C for up to 2 years.
- Recommended Storage Buffer
- 10 mM PBS