Formalin-fixed, paraffin-embedded Melanoma stained with Tyrosinase Rabbit Recombinant Monoclonal Antibody (TYR/2024R).

Tyrosinase Antibody (clone TYR/2024R)

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Recombinant Monoclonal
Applications:	Immunohistochemistry (general), Immunohistochemistry, Paraffin
Reactivity:	Human
Format:	Liquid

$379.00each

Catalog Number: LS-C751407-20

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Description: Tyrosinase antibody LS-C751407 is an unconjugated rabbit recombinant monoclonal antibody to human Tyrosinase. Validated for IHC.
Application: IHC, IHC-P
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Recombinant Antibodies
Alternative Names: CMM8 | LB24-AB | SHEP3 | SK29-AB | Monophenol monooxygenase | Tumor rejection antigen AB | TYR | OCA1A | Tyrosinase | OCAIA
Recommended Dilution: IHC-P: 0.5 - 1 µg/ml
UniProt Number: P14679
NCBI GenBank: NM_000372 | NP_000363.1
SwissProt: P14679

Target: Human Tyrosinase
Antigen Species: Human
Epitope: Recognizes a cluster of proteins between 70-80 kDa , identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
Gene Name: TYR