TRIM33 / TIF1-Gamma Antibody (HRP)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay |
| Reactivity: | Human |
| Format: | Liquid |
$300.00each
Catalog Number: LS-C502116-50
Catalog Number: LS-C502116
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- Description
- TIF1-Gamma antibody LS-C502116 is an HRP-conjugated rabbit polyclonal antibody to human TIF1-Gamma (TRIM33). Validated for ELISA.
- Application
- ELISA
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- Ectodermin homolog | ECTO | RET-FUSED GENE 7 | RFG7 | TF1G | TIF1GAMMA | TIFGAMMA | TIF1-gamma | PTC7 | RET-fused gene 7 protein | TIF1G | Tripartite motif-containing 33 | KIAA1113 | Protein Rfg7 | TRIM33 | Tripartite motif containing 33
- UniProt Number
- Q9UPN9
- NCBI GenBank
- NM_015906 | NP_056990.3
- SwissProt
- Q9UPN9
Target
- Target
- Human TRIM33 / TIF1-Gamma
- Antigen Species
- Human
- Epitope
- Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
- Gene Name
- TRIM33
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Isotype
- IgG
Immunogen
- Immunogen
- Recombinant Human E3 ubiquitin-protein ligase TRIM33 protein (1-273AA)
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Horseradish Peroxidase
- Format
- Liquid
- Formulation
- PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- PBS