Positive WB detected in:MCF-7 whole cell lysate,Jurkat whole cell lysate,Hela whole cell lysate,K562 whole cell lysate;All lanes: TRIM25 antibody at 3ug/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 71 kDa;Observed band size: 71,80 kDa;

TRIM25 Antibody

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Polyclonal
Applications:	Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general), Western Blot
Reactivity:	Human
Format:	Liquid

$300.00each

Catalog Number: LS-C500768-50

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Overview

Description: TRIM25 antibody LS-C500768 is an unconjugated rabbit polyclonal antibody to human TRIM25. Validated for ELISA, IF, IHC and WB.
Application: ELISA, IF, IHC, WB
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: EFP | Zinc finger protein 147 | Z147 | Zinc finger protein-147 | ZNF147 | Tripartite motif containing 25 | RING finger protein 147 | RNF147 | TRIM25 | Tripartite motif-containing 25
UniProt Number: Q14258
NCBI GenBank: NM_005082 | NP_005073.2
SwissProt: Q14258

Target

Target: Human TRIM25
Antigen Species: Human
Epitope: Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784).
Gene Name: TRIM25