Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with Thymidine Phosphorylase Rabbit Recombinant Monoclonal (TYMP/2890R).
TP / Thymidine Phosphorylase Antibody (clone TYMP/2890R, Azide-free, Carrier-free)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Recombinant Monoclonal |
| Applications: | Immunohistochemistry, Paraffin |
| Reactivity: | Human |
| Format: | Liquid |
$586.00each
Catalog Number: LS-C751119-100
Catalog Number: LS-C751119
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- Description
- Thymidine Phosphorylase antibody LS-C751119 is an unconjugated rabbit recombinant monoclonal antibody to human Thymidine Phosphorylase (TP). Validated for IHC.
- Application
- IHC-P
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Recombinant Antibodies
- Alternative Names
- ECGF1 | HPD-ECGF | MEDPS1 | MNGIE | MTDPS1 | PD-ECGF | Thymidine phosphorylase | PDECGF | ECGF | Gliostatin | TdRPase | TP | TYMP
- Recommended Dilution: IHC-P
- 1 - 2 µg/ml
- UniProt Number
- P19971
- NCBI GenBank
- NM_001953 | NP_001944.1
- SwissProt
- P19971
Target
- Target
- Human TP / Thymidine Phosphorylase
- Antigen Species
- Human
- Epitope
- Recognizes a protein (amino acid 482) of 55 kDa (in vivo 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5'-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites
- Gene Name
- TYMP
Antibody
- Host Species
- Rabbit
- Clonality
- Recombinant Monoclonal
- Clone
- TYMP/2890R
- Isotype
- IgG
- Origin Species
- Human
Immunogen
- Immunogen
- Recombinant full-length human Thymidine Phosphorylase (TP / PD-ECGF) protein. Antigen Molecular Weight: 55 kDa
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10 mM PBS
- Concentration
- 1 mg/mL
- Preservative
- No
- Purification Method
- Protein A/G Affinity
Storage & Handling
- Storage Conditions
- Store at -20°C to -80°C for up to 2 years.
- Recommended Storage Buffer
- 10 mM PBS