TNNI3 / Cardiac Troponin I Antibody
Primary AntibodyLSBio Guarantee
| Antibody: | Goat Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry, Frozen, Western Blot |
| Reactivity: | Human |
| Format: | Liquid |
$357.00each
Catalog Number: LS-C42578-0.2
Catalog Number: LS-C42578
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- Description
- Cardiac Troponin I antibody LS-C42578 is an unconjugated goat polyclonal antibody to human Cardiac Troponin I (TNNI3). Validated for ELISA, IF, IHC and WB.
- Application
- ELISA, IF, IHC-F, WB
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- CTnI | CMD1FF | CMD2A | RCM1 | Troponin I, cardiac | Troponin I, cardiac muscle | TNNI3 | Troponin I type 3 (cardiac) | Cardiac troponin I | CMH7
- UniProt Number
- P19429
- NCBI GenBank
- NM_000363 | NP_000354.4
- SwissProt
- P19429
Target
- Target
- Human TNNI3 / Cardiac Troponin I
- Antigen Species
- Human
- Epitope
- Recognizes human cardiac-specific troponin I, (TnI) an integral inhibitory protein of cardiac muscle which exists as a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin to form a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, enabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurement of blood TnI and TnT levels is an important diagnostic indicator of heart muscle damage, and can be used to differentiate between angina and myocardic infarction in patients with chest pain. Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro.
- Gene Name
- TNNI3
Antibody
- Host Species
- Goat
- Clonality
- Polyclonal
- Isotype
- IgG
Immunogen
- Immunogen
- Native human cardiac troponin I, purity greater than 98%.
- Immunogen Type
- Native Protein (Purified from Natural Source)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS