Formalin-fixed, paraffin-embedded human Parathyroid Mass stained with TNFS15 / VEGI Monoclonal Antibody (rVEGI /1283).
TNFSF15 / TL1A / VEGI Antibody (clone rVEGI/1283, Azide-free, Carrier-free)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Recombinant Monoclonal |
| Applications: | Immunohistochemistry, Paraffin |
| Reactivity: | Human |
| Format: | Liquid |
$586.00each
Catalog Number: LS-C751492-100
Catalog Number: LS-C751492
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- Description
- VEGI antibody LS-C751492 is an unconjugated mouse recombinant monoclonal antibody to human VEGI (TNFSF15 / TL1A). Validated for IHC.
- Application
- IHC-P
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Recombinant Antibodies
- Alternative Names
- TL1 | TL1A | TNF ligand-related molecule 1 | TNF superfamily ligand TL1A | VEGI192A | TNFSF15 | VEGI
- Recommended Dilution: IHC-P
- 1 - 2 µg/ml
- UniProt Number
- O95150
- NCBI GenBank
- NM_005118 | NP_005109.2
- SwissProt
- O95150
Target
- Target
- Human TNFSF15 / TL1A / VEGI
- Antigen Species
- Human
- Epitope
- VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.
- Gene Name
- TNFSF15
Antibody
- Host Species
- Mouse
- Clonality
- Recombinant Monoclonal
- Clone
- rVEGI/1283
- Isotype
- IgG1
- Light Chain
- Kappa Light Chain
- Origin Species
- Human
Immunogen
- Immunogen
- Recombinant full-length human VEGI protein. Antigen Molecular Weight: 22 kDa
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10 mM PBS
- Concentration
- 1 mg/mL
- Preservative
- No
- Purification Method
- Protein A/G Affinity
Storage & Handling
- Storage Conditions
- Store at -20°C to -80°C for up to 2 years.
- Recommended Storage Buffer
- 10 mM PBS