Western blot of MPYS in A-20 cell lysate with MPYS antibody at (A) 1 and (B) 2 ug/ml. Below: Immunocytochemistry of MPYS in A20 cells with MPYS antibody at 5 ug/ml.
TMEM173 / STING Antibody
| Antibody: | Rabbit Polyclonal |
| Applications: | Immunocytochemistry, Immunofluorescence, Immunohistochemistry (general), Western Blot |
| Reactivity: | Human, Mouse |
| Format: | Liquid |
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- Description
- STING antibody LS-C108557 is an unconjugated rabbit polyclonal antibody to STING (TMEM173) from human. It is reactive with human and mouse. Validated for ICC, IF and WB. Cited in 3 publications.
- Application
- ICC, IF, IHC, WB
- Reactivity
- Hu, Ms
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- ERIS | MITA | HSTING | Transmembrane protein 173 | TMEM173 | HMITA | Mediator of IRF3 activation | MPYS | NET23 | STING
- Recommended Dilution: WB
- 1 - 2 µg/ml
- UniProt Number
- Q86WV6
- SwissProt
- Q86WV6
Target
- Target
- Human TMEM173 / STING
- Antigen Species
- Human
- Gene Name
- STING1
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Isotype
- IgG
Immunogen
- Immunogen
- A 17 AA synthetic peptide near the C-Terminus of human MPYS. The immunogen is located within aa 260-310 of MPYS.
- Immunogen Type
- Synthetic Peptide (Linear)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS containing 0.02% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- Store at 4°C for up to 1 year.
- Recommended Storage Buffer
- PBS
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Parvatiyar K, Zhang Z, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA, Schenk M, Zeng S, Zhong W, Liu ZJ, Modlin RL, Liu YJ, Cheng G. Nature immunology. 2012 Dec;13:1155-61.
PubMed: 23142775 · PMC: PMC3501571
The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Zhang Z, Yuan B, Bao M, Lu N, Kim T, Liu YJ. Nature immunology. 2011 Oct;12:959-65.
PubMed: 21892174 · PMC: PMC3671854
Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS. Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, Pich A, Brinkmann MM, Schulz TF. Proceedings of the National Academy of Sciences of the United States of America. 2016;113:E1034-43.
PubMed: 26811480 · PMC: PMC4776510