Mouse TIM-4 transfected NRK cells stained with Rat anti-Mouse TIM-4. This image was taken for the unmodified form of this product. Other forms have not been tested.
TIMD4 / TIM4 / TIM-4 Antibody (clone RMT4-54)
Primary AntibodyLSBio Guarantee
| Antibody: | Rat Monoclonal |
| Applications: | Flow Cytometry, Immunofluorescence, Immunohistochemistry (general), Immunohistochemistry, Paraffin |
| Reactivity: | Mouse |
| Format: | Liquid |
$286.00each
Catalog Number: LS-C187579-0.1
Catalog Number: LS-C187579
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- Description
- TIM-4 antibody LS-C187579 is an unconjugated rat monoclonal antibody to mouse TIM-4 (TIMD4 / TIM4). Validated for Flow, IF and IHC.
- Application
- FC, IF, IHC, IHC-P
- Reactivity
- Ms
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- SMUCKLER | TIMD4 | TIM-4 | T-cell membrane protein 4 | TIM4 | TIMD-4 | TIM 4
- UniProt Number
- Q96H15
- NCBI GenBank
- NM_138379 | NP_612388.2
- SwissProt
- Q96H15
Target
- Target
- Mouse TIMD4 / TIM4 / TIM-4
- Antigen Species
- Mouse
- Epitope
- Clone RMT4-54 specifically recognizes mouse Tim-4 (T-cell immunoglobulin mucin 4), a transmembrane glycoprotein and member of the immunoglobulin superfamily, exclusively expressed by antigen-presenting cells, which acts as the natural ligand of Tim-1, involved in T-cell expansion and cytokine production. Tim-4 is reported to be crucial for the phagocytosis of apoptotic cells by peritoneal macrophages, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on DCs, enhances Th2 cell function. The TIM-4 gene locus is associated with predisposition to asthma in both mice and humans and may be considered as a candidate disease gene for asthma. Studies have shown that clone RMT4-54 significantly inhibits the efficient phagocytosis of apoptotic cells by PRMs (peritoneal resident Mac1+ cells), but not PEMs (peritoneal exudate Mac1+ cells) see for details.
- Gene Name
- TIMD4
Antibody
- Host Species
- Rat
- Clonality
- Monoclonal
- Clone
- RMT4-54
- Isotype
- IgG2a
Immunogen
- Immunogen
- Tim-4-Ig, consisting of amino acids 1-288 of mouse Tim-4, coupled with the Fc portion of mouse IgG2a.
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS