Immunohistochemistry of paraffin-embedded human brain tissue using TGFBR2 Antibody at dilution of 1:100

TGFBR2 Antibody

Antibody:	Rabbit Polyclonal
Applications:	Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general)
Reactivity:	Human
Format:	Liquid

$300.00each

Catalog Number: LS-C499922-50

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Description: TGFBR2 antibody LS-C499922 is an unconjugated rabbit polyclonal antibody to human TGFBR2. Validated for ELISA, IF and IHC.
Application: ELISA, IF, IHC
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: AAT3 | FAA3 | HNPCC6 | LDS2B | MFS2 | TGF-beta receptor type-2 | TGF-beta RII | TGFBR2 | TGFBRII | TGF-beta type II receptor | TGFbeta-RII | TbetaR-II | TGF beta Receptor II | TGF-beta receptor type II | TGF-beta receptor type IIB | TGFR-2 | LDS1B | RIIC | TAAD2
UniProt Number: P37173
NCBI GenBank: NM_003242 | NP_003233.4
SwissProt: P37173

Target: Human TGFBR2
Antigen Species: Human
Epitope: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
Gene Name: TGFBR2