LSBio
SUV39H2 Antibody (aa287-336)

SUV39H2 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

SUV39H2 Antibody (aa287-336)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Immunohistochemistry (general), Western Blot
Reactivity:Human
Format:Liquid
See all Human SUV39H2 antibodies →
$433.00each
Catalog Number: LS-C116360-100

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Overview

Description
SUV39H2 antibody LS-C116360 is an unconjugated rabbit polyclonal antibody to human SUV39H2 (aa287-336). Validated for WB. Cited in 4 publications.
Application
IHC, WB
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee.
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
H3-K9-HMTase 2 | Lysine N-methyltransferase 1B | Su(var)3-9 homolog 2 | SUV39H2 | KMT1B
UniProt Number
Q9H5I1
SwissProt
Q9H5I1

Target

Target
Human SUV39H2
Antigen Species
Human
Epitope
Human SUV39H2
Gene Name
SUV39H2

Antibody

Host Species
Rabbit
Clonality
Polyclonal

Immunogen

Immunogen
Synthetic peptide from internal of human SUV39H2 (D3DRT4, NP_078946 aa 287-336). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Galago, Mouse, Rabbit, Horse, Guinea pig (100%); Marmoset, Rat, Dog, Bovine, Pig, Xenopus (92%); Elephant, Bat, Opossum, Platypus (85%).
Immunogen Type
Synthetic Peptide (Linear)

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, 0.09% sodium azide, 2% sucrose
Concentration
0.5 mg/mL
Volume
100 Microliter
Preservative
Yes
Purification Method
Affinity Purified

Storage & Handling

Storage Conditions
Short term: Store at 2-8°C. Long term: Aliquot and store at -20°C. Avoid freeze/thaw cycles.
Recommended Storage Buffer
PBS

Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation. Velazquez Camacho O, Galan C, Swist-Rosowska K, Ching R, Gamalinda M, Karabiber F, De La Rosa-Velazquez I, Engist B, Koschorz B, Shukeir N, Onishi-Seebacher M, van de Nobelen S, Jenuwein T. eLife. 2017;6.

PubMed: 28760199 · PMC: PMC5538826


Complete loss of H3K9 methylation dissolves mouse heterochromatin organization. Thomas Montavon, Nicholas Shukeir, Galina Erikson, Bettina Engist, Megumi Onishi-Seebacher, Devon Ryan, Yaarub Musa, Gerhard Mittler, Alexandra Graff Meyer, Christel Genoud, Thomas Jenuwein. Nature communications. 2021 July;12:4359.

PubMed: 34272378 · PMC: PMC8285382


Regulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferases. Kei Fukuda, Chikako Shimura, Hisashi Miura, Akie Tanigawa, Takehiro Suzuki, Naoshi Dohmae, Ichiro Hiratani, Yoichi Shinkai. Communications biology. 2021 May;4:571.

PubMed: 33986449 · PMC: PMC8119675


HP1 maintains protein stability of H3K9 methyltransferases and demethylases. Ryo Maeda, Makoto Tachibana. EMBO reports. 2022 April;23:e53581.

PubMed: 35166421 · PMC: PMC8982598

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