LSBio
SLA Class II DR Antibody (clone 2E9/13, FITC)

Pig peripheral blood lymphocytes stained with Mouse anti-Pig SLA Class II DR followed by Goat anti-Mouse IgG:FITC. This image was taken for the unconjugated form of this product. Other forms have not been tested.

SLA Class II DR Antibody (clone 2E9/13, FITC)

Primary AntibodyLSBio Guarantee
Antibody:Mouse Monoclonal
Applications:Flow Cytometry
Reactivity:Pig
Format:Liquid
See all Pig SLA Class II DR antibodies →
$540.00each
Catalog Number: LS-C188278-0.1

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Overview

Description
SLA Class II DR antibody LS-C188278 is an FITC-conjugated mouse monoclonal antibody to pig SLA Class II DR. Validated for Flow. Cited in 4 publications.
Application
FC
Reactivity
Por
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Monoclonal Antibodies
Recommended Dilution
ApplicationDilution
FC0.0423611111111111

Target

Target
Pig SLA Class II DR
Antigen Species
Pig
Epitope
The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In pigs, this is referred to as the swine leukocyte antigen (SLA) region. There are 3 major MHC class II proteins encoded by the SLA which are SLA DP, SLA DQ and SLA DR. The antibody is specific for SLA DR molecules which are expressed on all B cells, antigen presenting cells and on certain subsets of resting and activated T cells. This clone reacts with lymphocytes from all outbred and miniature pigs so far tested, suggesting that it recognizes a monomorphic determinant of porcine SLA DR. Immunoprecipitates a heterodimer composed of two polypeptides of 28 and 35kD from NP-40 extracts of biotin surface-labeled porcine peripheral blood mononuclear cells. Clone 2E9/13 is reported to inhibit the mixed lymphocyte reaction and T cell stimulation induced by African swine fever virus and Staphylococcal enterotoxin B.

Antibody

Host Species
Mouse
Clonality
Monoclonal
Clone
2E9/13
Isotype
IgG2b

Immunogen

Immunogen
Porcine monocytes.
Immunogen Type
Cell-Based Immunization

Format

Conjugate/Label
Fluorescein Isothiocyanate
Format
Liquid
Formulation
PBS, 0.09% Sodium Azide, 1% BSA
Concentration
0.1 mg/mL
Preservative
Yes
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Protect from light. Microcentrifugation recommended if solution contains precipitate.
Recommended Storage Buffer
PBS

Retinoic acid facilitates inactivated transmissible gastroenteritis virus induction of CD8(+) T-cell migration to the porcine gut. Chen X, Tu C, Qin T, Zhu L, Yin Y, Yang Q. Scientific reports. 2016;6:24152.

PubMed: 27080036 · PMC: PMC4832189

Impact of TGEV infection on the pig small intestine. Lu Xia, Yunhan Yang, Jialu Wang, Yuchao Jing, Qian Yang. Virology journal. 2018 June;15:102.

PubMed: 29914507 · PMC: PMC6006930

Effects of virulent and attenuated transmissible gastroenteritis virus on the ability of porcine dendritic cells to sample and present antigen. Shanshan Zhao, Qi Gao, Tao Qin, Yinyan Yin, Jian Lin, Qinghua Yu, Qian Yang. Veterinary microbiology. 2014 June;171:74-86.

PubMed: 24742951 · PMC: PMC7117177

Differential response of porcine immature monocyte-derived dendritic cells to virulent and inactivated transmissible gastroenteritis virus. Shanshan Zhao, Qi Gao, Jian Lin, Mengfei Yan, Qinghua Yu, Qian Yang. Research in veterinary science. 2014 December;97:623-30.

PubMed: 25307113 · PMC: PMC7111762

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