Anti-SIRT6 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
SIRT6 / Sirtuin 6 Antibody (aa56-105)
| Antibody: | Rabbit Polyclonal |
| Applications: | Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot |
| Reactivity: | Human, Mouse |
| Format: | Liquid |
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- Description
- Sirtuin 6 antibody LS-B5589 is an unconjugated rabbit polyclonal antibody to Sirtuin 6 (SIRT6) (aa56-105) from human. It is reactive with human and mouse. Validated for IHC and WB. Cited in 3 publications.
- Application
- IHC, IHC-P, WB
- Reactivity
- Hu, Ms
- Intended Use
- Research Use Only
- Guarantees
- This product carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- SIR2-like protein 6 | Sirtuin type 6 | SIR2L6 | Sir2-related protein type 6 | Sirtuin 6 | SIRT6
- Recommended Dilution: IHC-P
- 10 µg/ml
- Recommended Dilution: WB
- 1.25 µg/ml
- UniProt Number
- Q8N6T7
- NCBI GenBank
- NM_016539 | NP_057623.2
- SwissProt
- Q8N6T7
Target
- Target
- SIRT6 / Sirtuin 6
- Antigen Species
- Human
- Specificity
- Human SIRT6
- Epitope
- Human SIRT6
- Gene Name
- SIRT6
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Origin Species
- Human
Immunogen
- Immunogen
- Synthetic peptide located between aa56-105 of human SIRT6 (Q8N6T7, NP_057623). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Monkey, Galago, Marmoset, Mouse, Hamster, Elephant, Dog, Bat, Pig, Opossum (100%); Gibbon, Rat, Bovine, Horse, Guinea pig, Platypus (92%); Turkey, Zebra finch, Chicken, Xenopus (84%).
- Immunogen Type
- Synthetic Peptide (Linear)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% sodium azide, 2% sucrose
- Concentration
- 1 mg/mL
- Volume
- 50 Microliter
- Animal Free
- No
- Carrier-Free
- Yes
- Preservative
- Yes
- Purification Method
- Protein A Affinity
Storage & Handling
- Storage Conditions
- Short term: Store at 2-8°C. Long term: Aliquot and store at -20°C. Avoid freeze/thaw cycles.
- Recommended Storage Buffer
- PBS
The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells. Choe M, Brusgard JL, Chumsri S, Bhandary L, Zhao XF, Lu S, Goloubeva OG, Polster BM, Fiskum GM, Girnun GD, Kim MS, Passaniti A. Journal of cellular biochemistry. 2015;116:2210-26.
PubMed: 25808624 · PMC: PMC4885214
Evaluation of the NAD+ biosynthetic pathway in ALS patients and effect of modulating NAD+ levels in hSOD1-linked ALS mouse models. Benjamin A Harlan, Kelby M Killoy, Mariana Pehar, Liping Liu, Johan Auwerx, Marcelo R Vargas. Experimental neurology. 2020 May;327:113219.
PubMed: 32014438 · PMC: PMC7089832
Effects of vinclozolin exposure on the expression and activity of SIRT1 and SIRT6 in the porcine ovary. G Gorczyca, K Wartalski, Z Tabarowski, M Duda. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2019 February;70.
PubMed: 31172974