SIRT2 antibody Western blot. All lanes: Anti SIRT2 at 0.5 ug/ml. WB: Recombinant Human SIRT2 Protein 0.5ng. Predicted band size: 39 kD. Observed band size: 39 kD.
SIRT2 / Sirtuin 2 Antibody (aa165-187)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot |
| Reactivity: | Human, Mouse, Non-Human Primate, Rat |
| Format: | Lyophilized |
$480.00each
Catalog Number: LS-C344019-100
Catalog Number: LS-C344019
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- Description
- Sirtuin 2 antibody LS-C344019 is an unconjugated rabbit polyclonal antibody to Sirtuin 2 (SIRT2) (aa165-187) from human. It is reactive with human, mouse, rat and other species. Validated for IHC and WB.
- Application
- IHC, IHC-P, WB
- Reactivity
- Hu, Ms, NHP, Rt
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- SIR2 | Sir2-related protein type 2 | SIR2L | SIR2L2 | Sirtuin 2 | Silent information regulator 2 | SIR2-like protein 2 | SIRT2 | Sirtuin type 2
- UniProt Number
- Q8IXJ6
- NCBI GenBank
- NM_030593 | NP_085096.1
- SwissProt
- Q8IXJ6
Target
- Target
- Human SIRT2 / Sirtuin 2
- Antigen Species
- Human
- Epitope
- Isoform 1 is expressed in heart, liver and skeletal muscle, weakly expressed in the cortex. Isoform 2 is strongly expressed in the cortex, weakly expressed in heart and liver. Weakly expressed in several malignancies including breast, liver, brain, kidney and prostate cancers compared to normal tissues. Weakly expressed in glioma cell lines compared to normal brain tissues (at protein level). Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. .
- Gene Name
- SIRT2
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
Immunogen
- Immunogen
- A synthetic peptide corresponding to a sequence in the middle region of human SIRT2(165-187 aa YTQNIDTLERIAGLEQEDLVEAH), different from the related mouse and rat sequences by three amino acids.
- Immunogen Type
- Synthetic Peptide (Linear)
Format
- Conjugate/Label
- Unconjugated
- Format
- Lyophilized
- Formulation
- Lyophilized from 0.2mg Na2HPO4, 5mg BSA, 0.9mg NaCl, 0.05mg sodium azide.
- Concentration
- 0.5 mg/mL
- Preservative
- Yes
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- At -20°C for 1 year. After reconstitution, at 4°C for 1 month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- NaCl