Human peripheral blood lymphocytes stained with Mouse anti-Human siglec-10:FITC This image was taken for the unconjugated form of this product. Other forms have not been tested.

SIGLEC10 Antibody (clone 5G6, FITC)

Primary AntibodyLSBio Guarantee

Antibody:	Mouse Monoclonal
Applications:	Flow Cytometry
Reactivity:	Human
Format:	Liquid

$335.00each

Catalog Number: LS-C187564-0.1

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Overview

Description: SIGLEC10 antibody LS-C187564 is an FITC-conjugated mouse monoclonal antibody to human SIGLEC10. Validated for Flow.
Application: FC
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Monoclonal Antibodies
Alternative Names: SIGLEC-10 | Siglec-like gene 2 | Siglec-like protein 2 | SIGLEC10 | PRO940 | SLG2
UniProt Number: Q96LC7
SwissProt: Q96LC7

Target

Target: Human SIGLEC10
Antigen Species: Human
Epitope: Clone 5G6 specifically recognizes human Siglec-10 (Sialic acid-binding Ig-like lectin 10), a putative adhesion molecule and member of the Ig superfamily, expressed by monocytes, B cells, eosinophils, and at a higher level by a subpopulation of CD16+CD56- natural killer (NK) cells. Structurally, Siglec-10 is most similar to the CD33-related group of Siglecs, and preferentially binds to glycoconjugates containing alpha-2,3- or alpha-2,6-linked sialic acid. Studies have shown that Siglec-10 acts as a substrate for VAP-1 (Vascular adhesion protein-1), a glycoprotein expressed on endothelium during inflammation, which is involved in primary amine oxidation and leucocyte trafficking, see for details. This interaction between Siglec-10 and VAP-1, implicates Siglec-10 in endothelial lymphocyte adhesion and in the modulation of the inflammatory microenvironment. Studies have shown that clone 5G6 does not cross-react with Siglecs 3, 5, 7, 8 and 9, see for details.
Gene Name: SIGLEC10

Antibody

Host Species: Mouse
Clonality: Monoclonal
Clone: 5G6
Isotype: IgG1

Immunogen

Immunogen: Recombinant human Siglec-10, fused with the Fc region of human IgG.
Immunogen Type: Recombinant Immunogen

Format

Conjugate/Label: Fluorescein Isothiocyanate
Format: Liquid
Formulation: PBS, 0.09% Sodium Azide, 1% BSA
Concentration: 0.1 mg/mL
Preservative: Yes
Purification Method: Protein G Affinity

Storage & Handling

Storage Conditions: Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Protect from light. Microcentrifugation recommended if solution contains precipitate.
Recommended Storage Buffer: PBS