Western blot of whole cell lysate from A549 human lung adenocarcinoma cells probed with Rabbit anti-Mouse SIGIRR at 0.5(A), 1(B) and 2(C) ug/ml

SIGIRR Antibody (C-Terminus)

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Antibody:	Rabbit Polyclonal
Applications:	Immunohistochemistry, Frozen, Western Blot
Reactivity:	Mouse
Format:	Liquid

$403.00each

Catalog Number: LS-C187825-0.1

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Description: SIGIRR antibody LS-C187825 is an unconjugated rabbit polyclonal antibody to mouse SIGIRR (C-Terminus). Validated for IHC and WB.
Application: IHC-F, WB
Reactivity: Ms
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: TIR8 | Toll/interleukin-1 receptor 8 | SIGIRR
UniProt Number: Q6IA17
NCBI GenBank: NM_021805 | NP_068577.2
SwissProt: Q6IA17

Target: Mouse SIGIRR
Antigen Species: Mouse
Epitope: Recognizes the Single Ig IL-1-related receptor (SIGIRR), a member of the Toll-like receptor-interleukin 1 receptor superfamily, defined by an intracellular Toll-IL-1R (TIR) domain. SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signalling pathways. It interacts with TLR4, TLR5, TLR9 and IL-1R through the extracellular Ig domain, or the intracellular TIR domain. The Ig domain interferes with the heterodimerization of IL-1R while the intracellular TIR domain inhibits both IL-1 and LPS signalling by attenuating the recruitment of receptor-proximal signalling components to TLR4. SIGIRR is expressed in kidney, colon, small intestine, lung, spleen and liver. It is not expressed in brain and muscle.
Gene Name: SIGIRR

Immunogen: A peptide corresponding to 15 aa at the C-Terminus of mouse SIGIRR.
Immunogen Type: Peptide

Storage Conditions: Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Recommended Storage Buffer: PBS