Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
SELL / L-Selectin / CD62L Antibody (clone FMC46)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Flow Cytometry, Immunohistochemistry (general), Immunohistochemistry, Frozen, Immunohistochemistry, Paraffin, Immunoprecipitation |
| Reactivity: | Human |
| Format: | Liquid |
$392.00each
Catalog Number: LS-C43268-0.2
Catalog Number: LS-C43268
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- Description
- CD62L antibody LS-C43268 is an unconjugated mouse monoclonal antibody to human CD62L (SELL / L-Selectin). Validated for Flow, IHC and IP.
- Application
- FC, IHC, IHC-F, IHC-P, IP
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- CD62L | CD62L antigen | LAM-1 | LAM1 | LECAM1 | LEU8 | Leukocyte adhesion molecule 1 | Lyam-1 | LSEL | gp90-MEL | HLHRc | PLNHR | L-selectin | Leu-8 | Selectin L | SELL | LNHR | LYAM1 | Lymph node homing receptor | Lymphocyte adhesion molecule 1 | TQ1 | Pln homing receptor | CD26L
- Recommended Dilution: FC
- 1:50 - 1:100
- Recommended Dilution: IHC-P
- 10 µg/ml
- NCBI GenBank
- NM_000655
Target
- Target
- Human SELL / L-Selectin / CD62L
- Antigen Species
- Human
- Epitope
- Recognizes human CD62L, also known a L-selectin, a 74-95kD member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes. CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of na-ve lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains. The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- FMC46
- Isotype
- IgG2b
Immunogen
- Immunogen
- PHA stimulated lymphoblasts.
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS