S100A8 / MRP8 Antibody (clone 8-5C2, Biotin)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general), Immunohistochemistry, Paraffin |
| Reactivity: | Human |
| Format: | Lyophilized |
$799.00each
Catalog Number: LS-C96231-100
Catalog Number: LS-C96231
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- Description
- MRP8 antibody LS-C96231 is a biotin-conjugated mouse monoclonal antibody to human MRP8 (S100A8). Validated for ELISA and IHC.
- Application
- ELISA, IHC, IHC-P
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- 60B8AG | CFAG | CAGA | Calgranulin A | Calgranulin-A | Calprotectin L1L subunit | Cystic fibrosis antigen | CGLA | L1Ag | NIF | p8 | Protein S100-A8 | MRP8 | Urinary stone protein band A | CP-10 | MA387 | MRP-8 | S100A8
- UniProt Number
- P05109
- NCBI GenBank
- NM_002964 | NP_002955.2
- SwissProt
- P05109
Target
- Target
- Human S100A8 / MRP8
- Antigen Species
- Human
- Epitope
- The antigen is MRP8, the epitope is suspected in the central portion of the peptide. Antigen distribution: Isolated cells: The antigen is found in granulocytes and monocytes but not in other blood cells. In cultured monocytes, maximum MRP8 expression is found after 3 - 4 days. Myeloid leukaemia stains positively. Tissue sections: MRP8 is found in a distinct subpopulation of inflammatory perivascular infiltrates of the myelo-monocytic lineage. Macrophages synthesise MRP8 increasingly during the late stages of inflammation. A low MRP8 (and high MRP- 14) expression by macrophages was also reported in granulomatous diseases such as tuberculosis and sarcoidis. In non-granulomatous chronic inflammatory diseases such as chronic rheumatoid arthritis or chronic rejection after allograft transplantation, MRP8 and MRP14 positive cells consist of different subpopulations. Specificity: Human: MRP8 in stimulated monocytes and macrophages in late phase or chronic inflammation. Other: The antibody reacts with bovine spleen but does not react with rat tissues. It shows a diffuse reaction with swine spleen.
- Gene Name
- S100A8
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- 8-5C2
- Origin Species
- Human
Immunogen
- Immunogen
- Cultured human monocytes
- Immunogen Type
- Cell-Based Immunization
Format
- Conjugate/Label
- Biotin
- Format
- Lyophilized
- Formulation
- Lyophilized from PBS pH 7.2, 10mg/ml BSA, 0.01% thimerosal
- Preservative
- Yes
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- Store at 4°C.
- Recommended Storage Buffer
- PBS