Positive WB detected in:Mouse brain tissue;All lanes:RBBP6 antibody at 2.7?g/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 202,198,14,107 KDa;Observed band size: 202 KDa;

RBBP6 Antibody (aa51-97)

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Polyclonal
Applications:	Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general), Western Blot
Reactivity:	Human, Mouse
Format:	Liquid

$300.00each

Catalog Number: LS-C501206-50

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Overview

Description: RBBP6 antibody LS-C501206 is an unconjugated rabbit polyclonal antibody to RBBP6 (aa51-97) from human. It is reactive with human and mouse. Validated for ELISA, IF, IHC and WB.
Application: ELISA, IF, IHC, WB
Reactivity: Hu, Ms
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: RBBP6 | p2P-R | PACT | RBQ1 | MY038 | p2PR | Protein P2P-R | RB-binding Q-protein 1 | RBQ-1 | SNAMA
UniProt Number: Q7Z6E9
NCBI GenBank: NM_006910 | NP_008841.2
SwissProt: Q7Z6E9

Target

Target: Human RBBP6
Antigen Species: Human
Epitope: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).
Gene Name: RBBP6