Western blot analysis: HL60 cells were treated with camptothecin for 24 hours.

RB1 / Retinoblastoma / RB Antibody (clone 172C1094)

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Antibody:	Mouse Monoclonal
Applications:	Immunohistochemistry (general), Western Blot
Reactivity:	Human, Mouse
Format:	Liquid

$394.00each

Catalog Number: LS-C510-0.1

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Description: RB antibody LS-C510 is an unconjugated mouse monoclonal antibody to RB (RB1 / Retinoblastoma) from human. It is reactive with human and mouse. Validated for IHC and WB.
Application: IHC, WB
Reactivity: Hu, Ms
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Monoclonal Antibodies
Alternative Names: p105-Rb | Osteosarcoma | PRb | RB1 | Retinoblastoma | Retinoblastoma 1 | OSRC | RB | Pp110 | Rb
Recommended Dilution: WB: 2 µg/ml
UniProt Number: P06400
NCBI GenBank: NM_000321 | NP_000312.2
SwissProt: P06400

Target: Human RB1 / Retinoblastoma / RB
Antigen Species: Human
Epitope: recognizes cleaved Rb (DRb-p70). Does not recognize full-length Rb. In camptothecin treated HL60, an ~68 kD band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).
Gene Name: RB1

Immunogen: A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb.
Immunogen Type: Synthetic Peptide (Linear)

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