RB1 / Retinoblastoma / RB Antibody (Cleaved, clone 172C1094, Azide-free)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Immunohistochemistry (general), Immunohistochemistry, Frozen, Immunohistochemistry, Paraffin, Western Blot |
| Reactivity: | Human, Mouse |
| Format: | Liquid |
$394.00each
Catalog Number: LS-C368320-0.1
Catalog Number: LS-C368320
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- Description
- RB antibody LS-C368320 is an unconjugated mouse monoclonal antibody to RB (RB1 / Retinoblastoma) (Cleaved) from human. It is reactive with human and mouse. Validated for IHC and WB.
- Application
- IHC, IHC-F, IHC-P, WB
- Reactivity
- Hu, Ms
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- p105-Rb | Osteosarcoma | PRb | RB1 | Retinoblastoma | Retinoblastoma 1 | OSRC | RB | Pp110
- Recommended Dilution: IHC-F
- 1:10 - 1:500
- UniProt Number
- P06400
- NCBI GenBank
- NM_000321 | NP_000312.2
- SwissProt
- P06400
Target
- Target
- Human RB1 / Retinoblastoma / RB
- Antigen Species
- Human
- Epitope
- Human RB1 / Retinoblastoma / RB. The antibody recognizes cleaved Rb (DRb-p70). The antibody does not recognize full-length Rb. In camptothecin treated HL60, an ~68 kD band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).
- Gene Name
- RB1
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- 172C1094
- Isotype
- IgG1
Immunogen
- Immunogen
- A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb.
- Immunogen Type
- Synthetic Peptide (Linear)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS. No stabilizing proteins added.
- Concentration
- 1 mg/mL
- Preservative
- No
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- PBS