RASGRP1 / RASGRP Antibody (Biotin)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay |
| Reactivity: | Human |
| Format: | Liquid |
$300.00each
Catalog Number: LS-C499665-50
Catalog Number: LS-C499665
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- Description
- RASGRP antibody LS-C499665 is a biotin-conjugated rabbit polyclonal antibody to human RASGRP (RASGRP1). Validated for ELISA.
- Application
- ELISA
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- CALDAG-GEFI | HRasGRP1 | Ras activator rasgrp | RAS guanyl-releasing protein 1 | RASGRP1 | CALDAG-GEFII | Ras guanyl-releasing protein | RASGRP
- UniProt Number
- O95267
- NCBI GenBank
- NM_005739 | NP_005730.2
- SwissProt
- O95267
Target
- Target
- Human RASGRP1 / RASGRP
- Antigen Species
- Human
- Epitope
- Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332).
- Gene Name
- RASGRP1
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Isotype
- IgG
Immunogen
- Immunogen
- Recombinant Human RAS guanyl-releasing protein 1 protein (594-716AA)
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Biotin
- Format
- Liquid
- Formulation
- PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- PBS