PV1 / PLVAP Antibody (clone MECA-32)
Primary AntibodyLSBio Guarantee
| Antibody: | Rat Monoclonal |
| Applications: | Immunohistochemistry (general), Immunohistochemistry, Frozen |
| Reactivity: | Mouse |
| Format: | Liquid |
$286.00each
Catalog Number: LS-C58134-0.1
Catalog Number: LS-C58134
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- Description
- PLVAP antibody LS-C58134 is an unconjugated rat monoclonal antibody to mouse PLVAP (PV1). Validated for IHC.
- Application
- IHC, IHC-F
- Reactivity
- Ms
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- gp68 | FELS | Plasmalemma vesicle protein 1 | PV-1 | PLVAP | PV1
- Recommended Dilution: IHC-F
- 1:25 - 1:100
- UniProt Number
- Q9BX97
- NCBI GenBank
- NM_031310 | NP_112600.1
- SwissProt
- Q9BX97
Target
- Target
- Mouse PV1 / PLVAP
- Antigen Species
- Mouse
- Epitope
- Recognizes murine plasmalemma vesicle-associated protein (PLVAP), a 60kD protein which is otherwise known as MECA-32 and PV-1. PLVAP is a transmembrane homodimer which is associated with endothelial cell caveolae and fenestrae. In adult and embryonic mice, PLVAP is primarily expressed on endothelial tissues but shows restricted distribution in the skeletal, cardiac and brain tissues. In embryonic mice, PLVAP expression, on the vasculature associated with blood brain barrier has been reported to be developmentally regulated. In humans, PLVAP is selectively up-regulated in a variety of high-grade brain tumors, including glioblastoma and metastatic carcinoma, as well as other cerebral disorders associated with blood-brain barrier disruption, such as acute ischemia. PLVAP represents a novel marker of brain tumor angiogenesis and integrity of the blood-brain barrier and is a potential therapeutic target.
- Gene Name
- PLVAP
Antibody
- Host Species
- Rat
- Clonality
- Monoclonal
- Clone
- MECA-32
- Isotype
- IgG2a
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS