Positive WB detected in:Mouse spleen tissue,Mouse lung tissue,Mouse kidney tissue,Mouse brain tissue;All lanes:PRMT7 antibody at 6.2ug/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 79,63,74,64 kDa;Observed band size: 79 kDa;

PRMT7 Antibody

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Polyclonal
Applications:	Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry, Paraffin, Western Blot
Reactivity:	Human, Mouse
Format:	Liquid

$300.00each

Catalog Number: LS-C502013-50

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Overview

Description: PRMT7 antibody LS-C502013 is an unconjugated rabbit polyclonal antibody to PRMT7 from human. It is reactive with human and mouse. Validated for ELISA, IF, IHC and WB.
Application: ELISA, IF, IHC-P, WB
Reactivity: Hu, Ms
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: KIAA1933 | PRMT7
Recommended Dilution: IF/ICC: 1:50 - 1:200
Recommended Dilution: IHC-P: 1:20 - 1:200
Recommended Dilution: WB: 1:500 - 1:5000
UniProt Number: Q9NVM4
NCBI GenBank: NM_019023 | NP_061896.1
SwissProt: Q9NVM4

Target

Target: Human PRMT7
Antigen Species: Human
Epitope: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
Gene Name: PRMT7