Formalin-fixed, paraffin-embedded human Pituitary Gland stained with ACTH Mouse Recombinant Monoclonal Antibody (r57).
POMC / Proopiomelanocortin Antibody (N-Terminus, clone r57, Azide-free, Carrier-free)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Recombinant Monoclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunohistochemistry, Paraffin |
| Reactivity: | Human |
| Format: | Liquid |
$586.00each
Catalog Number: LS-C751311-100
Catalog Number: LS-C751311
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- Description
- Proopiomelanocortin antibody LS-C751311 is an unconjugated mouse recombinant monoclonal antibody to human Proopiomelanocortin (POMC) (N-Terminus). Validated for ELISA and IHC.
- Application
- ELISA, IHC-P
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Recombinant Antibodies
- Alternative Names
- Alpha-MSH | ACTH | Adrenocorticotropin | Adrenocorticotropic hormone | Beta-LPH | CLIP | Gamma-MSH | Lipotropin gamma | LPH | Melanotropin alpha | Met-enkephalin | Melanotropin beta | NPP | POMC | Pro-ACTH-endorphin | Lipotropin beta | Melanotropin gamma | MSH | Proopiomelanocortin | Beta-endorphin | Beta-MSH | Gamma-LPH | POC | Pro-opiomelanocortin
- Recommended Dilution: IHC-P
- 0.5 - 1 µg/ml
- UniProt Number
- P01189
- NCBI GenBank
- NM_000939 | NP_000930.1
- SwissProt
- P01189
Target
- Target
- Human POMC / Proopiomelanocortin
- Antigen Species
- Human
- Epitope
- ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH) - does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
- Gene Name
- POMC
Antibody
- Host Species
- Mouse
- Clonality
- Recombinant Monoclonal
- Clone
- r57
- Isotype
- IgG1
- Light Chain
- Kappa Light Chain
- Origin Species
- Human
Immunogen
- Immunogen
- N-Terminus fragment of human ACTH conjugated to KLH. Antigen Molecular Weight: ACTH is ~5 kDa , and the POMC precursor is ~30 kDa . The molecular weight of POMC depends upon isoform variation and post-translational modifications.
- Immunogen Type
- Small Molecule Hapten
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10 mM PBS
- Concentration
- 1 mg/mL
- Preservative
- No
- Purification Method
- Protein A/G Affinity
Storage & Handling
- Storage Conditions
- Store at -20°C to -80°C for up to 2 years.
- Recommended Storage Buffer
- 10 mM PBS