LSBio
Polyclonal Rabbit APP / Beta Amyloid Precursor Antibody (C-Terminus, IHC, WB)

IHC of rat brain with Rabbit anti-amyloid precursor protein (RABBIT ANTI AMYLOID PRECURSOR PROTEIN (C-TERMINAL)).

Polyclonal Rabbit APP / Beta Amyloid Precursor Antibody (C-Terminus, IHC, WB)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Immunohistochemistry, Paraffin, Western Blot
Reactivity:Human, Mouse, Rat
Format:Liquid
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$418.00each
Catalog Number: LS-C42820-0.1

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Overview

Description
Beta Amyloid Precursor antibody LS-C42820 is an unconjugated rabbit polyclonal antibody to Beta Amyloid Precursor (APP) (C-Terminus) from human, mouse and rat. Validated for IHC and WB.
Application
IHC-P, WB
Reactivity
Hu, Ms, Rt
Intended Use
RUO
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
ABPP | A4 | ABETA | AD1 | Alzheimer disease | Amyloid beta | APP | Beta-amyloid peptide | APPI | Beta amyloid | CVAP | AAA | PN2 | PreA4 | Amyloid beta A4 protein | Peptidase nexin-II | CTFgamma | PN-II | Protease nexin-II
Recommended Dilution: WB
1:500 - 1:1000
UniProt Number
P05067
NCBI GenBank
NM_000484, NP_000475.1
SwissProt
P05067

Target

Target
APP / Beta Amyloid Precursor
Epitope
Recognizes both intact Amyloid Precursor Protein (APP), and also the C99 fragment generated by Beta-secretase. The sequence recognized by this corresponds to amino acids 85-99 of the C99 fragment. The C99 fragment itself is a substrate for gamma-secretase to generate the 4 kD beta amyloid peptide, found in the brains of Alzheimer's disease patients. APP also inhibits Notch signaling through it's interaction with NUMB. Has been used successfully for the detection of the ~14 kD beta C-terminal fragment of APP, produced as a result of cleavage by BACE1 using western blotting -in rat retinal lysates.
Gene Name
APP

Antibody

Host Species
Rb
Clonality
Polyclonal
Isotype
IgG

Immunogen

Immunogen
Synthetic peptide corresponding to amino acids 737-751 of human APP (C-TERMINAL).
Immunogen Type
SP-Lin

Format

Conjugate/Label
Unconj
Format
Liquid
Formulation
PBS, 0.02% Sodium Azide
Concentration
1 mg/mL
Preservative
Yes
Purification Method
Other

Storage & Handling

Storage Conditions
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Recommended Storage Buffer
PBS

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