LSBio
Polyclonal Rabbit anti-Human WTAP Antibody (IHC, IF, WB)

Positive WB detected in:Mouse kidney tissue,Rat heart tissue,Rat liver tissue;All lanes:WTAP antibody at 3?g/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size:45,18 KDa;Observed band size: 45 KDa;

Polyclonal Rabbit anti-Human WTAP Antibody (IHC, IF, WB)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general), Western Blot
Reactivity:Human, Mouse, Rat
Format:Liquid
See all Human WTAP antibodies →
$300.00each
Catalog Number: LS-C500833-50

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Overview

Description
WTAP antibody LS-C500833 is an unconjugated rabbit polyclonal antibody to WTAP from human. It is reactive with human, mouse and rat. Validated for ELISA, IF, IHC and WB.
Application
ELISA, IF, IHC, WB
Reactivity
Hu, Ms, Rt
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
HFL(2)D | KIAA0105 | PNAS-132 | WTAP | WT1-associated protein | Female-lethal(2)D homolog
UniProt Number
Q15007
NCBI GenBank
NM_004906 | NP_004897.2
SwissProt
Q15007

Target

Target
Human WTAP
Antigen Species
Human
Epitope
Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).
Gene Name
WTAP

Antibody

Host Species
Rabbit
Clonality
Polyclonal
Isotype
IgG

Immunogen

Immunogen
Recombinant Human Pre-mRNA-splicing regulator WTAP protein (1-151AA)
Immunogen Type
Recombinant Immunogen

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Preservative
Yes
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

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