LSBio
Polyclonal Rabbit anti-Human TRB3 / TRIB3 Antibody (IHC)

Immunohistochemistry of paraffin-embedded human kidney tissue using TRIB3 Antibody at dilution of 1:100

Polyclonal Rabbit anti-Human TRB3 / TRIB3 Antibody (IHC)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general)
Reactivity:Human
Format:Liquid
See all Human TRB3 / TRIB3 antibodies →
$300.00each
Catalog Number: LS-C501475-50

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Overview

Description
TRIB3 antibody LS-C501475 is an unconjugated rabbit polyclonal antibody to human TRIB3 (TRB3). Validated for ELISA and IHC.
Application
ELISA, IHC
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
C20orf97 | NIPK | SINK | TRB-3 | TRIB3 | TRB3 | DJ1103G7.3 | SKIP3 | Tribbles homolog 3
UniProt Number
Q96RU7
NCBI GenBank
NM_021158 | NP_066981.2
SwissProt
Q96RU7

Target

Target
Human TRB3 / TRIB3
Antigen Species
Human
Epitope
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.
Gene Name
TRIB3

Antibody

Host Species
Rabbit
Clonality
Polyclonal
Isotype
IgG

Immunogen

Immunogen
Recombinant human Tribbles homolog 3 protein (152-325AA)
Immunogen Type
Recombinant Immunogen

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Preservative
Yes
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

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