LSBio
Polyclonal Rabbit anti-Human SNX27 Antibody (IHC, WB)

Positive WB detected in:HepG2 whole cell lysate,Jurkat whole cell lysate,A549 whole cell lysate,Mouse brain tissue,Rat heart tissue,Rat liver tissue;All lanes:SNX27 antibody at 3.5?g/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 62,60,53,28 KDa;Observed band size: 62,53 KDa;

Polyclonal Rabbit anti-Human SNX27 Antibody (IHC, WB)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general), Western Blot
Reactivity:Human, Mouse, Rat
Format:Liquid
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$300.00each
Catalog Number: LS-C501445-50

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Overview

Description
SNX27 antibody LS-C501445 is an unconjugated rabbit polyclonal antibody to SNX27 from human. It is reactive with human, mouse and rat. Validated for ELISA, IHC and WB.
Application
ELISA, IHC, WB
Reactivity
Hu, Ms, Rt
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
KIAA0488 | MY014 | SNX27 | Sorting nexin family member 27 | Sorting nexin-27 | MRT1
UniProt Number
Q96L92
NCBI GenBank
NM_030918 | NP_112180.4
SwissProt
Q96L92

Target

Target
Human SNX27
Antigen Species
Human
Epitope
Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.
Gene Name
SNX27

Antibody

Host Species
Rabbit
Clonality
Polyclonal
Isotype
IgG

Immunogen

Immunogen
Recombinant Human Sorting nexin-27 protein (458-497AA)
Immunogen Type
Recombinant Immunogen

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Preservative
Yes
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

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