LSBio
Polyclonal Rabbit anti-Human RPS6KA4 / MSK2 / RSK-B Antibody (IF, WB)

Positive WB detected in:U251 whole cell lysate,Mouse kidney tissue,Mouse brain tissue;All lanes: RPS6KA4 antibody at 3ug/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 86,85 kDa;Observed band size: 86 kDa;

Polyclonal Rabbit anti-Human RPS6KA4 / MSK2 / RSK-B Antibody (IF, WB)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general), Western Blot
Reactivity:Human, Mouse
Format:Liquid
See all Human RPS6KA4 / MSK2 / RSK-B antibodies →
$300.00each
Catalog Number: LS-C499711-50

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Overview

Description
RSK-B antibody LS-C499711 is an unconjugated rabbit polyclonal antibody to RSK-B (RPS6KA4 / MSK2) from human. It is reactive with human and mouse. Validated for ELISA, IF and WB.
Application
ELISA, IF, IHC, WB
Reactivity
Hu, Ms
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
MSK2 | RPS6KA4 | RSKB | Ribosomal protein kinase B | RSK-B | S6K-alpha-4
UniProt Number
O75676
NCBI GenBank
NM_003942 | NP_003933.1
SwissProt
O75676

Target

Target
Human RPS6KA4 / MSK2 / RSK-B
Antigen Species
Human
Epitope
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.
Gene Name
RPS6KA4

Antibody

Host Species
Rabbit
Clonality
Polyclonal
Isotype
IgG

Immunogen

Immunogen
Recombinant Human Ribosomal protein S6 kinase alpha-4 protein (237-393AA)
Immunogen Type
Recombinant Immunogen

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Preservative
Yes
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

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