LSBio
Polyclonal Rabbit anti-Human HCN1 Antibody (WB)

Polyclonal Rabbit anti-Human HCN1 Antibody (WB)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay, Western Blot
Reactivity:Human, Mouse, Rabbit, Rat
Format:Liquid
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$849.00each
Catalog Number: LS-C15642-100

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Overview

Description
HCN1 antibody LS-C15642 is an unconjugated rabbit polyclonal antibody to HCN1 from human. It is reactive with human, mouse, rat and other species. Validated for ELISA and WB.
Application
ELISA, WB
Reactivity
Hu, Ms, Rb, Rt
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
BCNG1 | BCNG-1 | HAC2 | HAC-2 | HCN1
Recommended Dilution: ELISA
1:10000 - 1:100000
UniProt Number
O60741
NCBI GenBank
AAC39759.1 | NM_021072
SwissProt
O60741

Target

Target
Human HCN1
Antigen Species
Human
Epitope
The pore region of HCN1 (HCNP15-P) is very conserved among various HCNs. HCN1: mouse, rat, human, rabbit=100%; HCN2: mouse, rat, human (86%); HCN3: mouse (95%), rat (90%); HCN4: rat, human (95%). The HCNP15-P sequence is also conserved in insect (Helothis virescens, 78%), Drosophila (78%) and Sea urchin (S. purpuratus, 69%) HCNs. Therefore, antibodies to HCNP15-P should react with most HCNs and related sequences. Antibody reactivity in various species is not known. The HCNP15-P control peptide, because of its low MW (<3kD), is not suitable for Western. It should be used for ELISA or antibody blocking experiments (use 5-10 ug control peptide per 1 ug of aff pure IgG or 1 ul antiserum) to confirm antibody specificity. This antibody may be useful in studying various HCNs and to examine the possibility of immunoblocking the pore region and impact on the functionality of HCNs proteins.
Gene Name
HCN1

Antibody

Host Species
Rabbit
Clonality
Polyclonal
Isotype
IgG

Immunogen

Immunogen
A 23 aa peptide sequence corresponding to the pore region of human HCN1 corresponding to amino acids 346-368.
Immunogen Type
Peptide

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, pH 7.4, 0.1% BSA
Concentration
1 mg/mL
Preservative
No
Purification Method
Affinity Purified

Storage & Handling

Storage Conditions
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles. Store undiluted.
Recommended Storage Buffer
PBS

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